The only FDA-approved treatment for patients with Lysosomal Acid Lipase Deficiency (LAL-D)1

KANUMA® (sebelipase alfa) is a hydrolytic lysosomal cholesteryl ester and triacylglycerol–specific enzyme indicated for the treatment of patients with a diagnosis of LAL-D.1

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KANUMA is administered as an intravenous infusion under the supervision of a healthcare professional.1 For more information, download the full Prescribing Information and Dosing and Administration brochure below:

Download Full Prescribing Information

Download Dosing And Administration Brochure

Getting Started on Kanuma® (sebelipase alfa)

KANUMA has been approved by the U.S. Food and Drug Administration as a treatment for patients with a diagnosis of LAL-D.1

Here’s how you can get your patients with LAL-D started on KANUMA:

Call the OneSource™ patient support program at 1-888-765-4747.

Ask your patient to sign the patient consent form to start working with his/her Nurse Case Manager.

Your office should complete the Statement of Medical Necessity (SMN) form and fax it to 1-800-420-5150 or email to


Patient Consent Form


SMN Form

We’re Here to Help

Once you have decided that KANUMA® (sebelipase alfa) is right for your patient, OneSource is here to help. Alexion’s objective is that every patient with LAL-D who can benefit from KANUMA will have access to it. After your patient signs up, they will be matched with a dedicated Alexion nurse case manager who can help answer any questions about KANUMA or LAL-D.

OneSource is staffed by nurse case managers who provide one-to-one education, assistance with funding options and access to KANUMA, as well as ongoing treatment support for your patients living with LAL-D, and their caregivers.

Our nurse case managers provide personalized support for your patients and their caregivers:

  • Assistance from a dedicated nurse case manager
  • Answers to questions about LAL-D or KANUMA
  • Resources and education on the infusion process
  • Help connecting people with other families affected by LAL-D

Financial assistance programs can help with out-of-pocket expenses for KANUMA:

  • The Alexion Commercial Co-pay Program can limit out-of-pocket expense to $5 for qualifying patients with commercial insurance
  • OneSource can also provide referrals to independent foundations for patients without commercial insurance and for other treatment-related costs
  • OneSource nurse case managers are reimbursement experts that can also help provide information and guidance regarding the insurance approval process for benefits investigation and coverage

Help get your patient connected

with their OneSource

nurse case manager


Monday through Friday,

8:30 AM to 5 PM (ET)